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2001 JUL 11 - (NewsRx.com & NewsRx.net) --
A Georgetown University Medical Center researcher has found that a certain type of CD4(+) T-cell, a type which travels through the lymph nodes, increases in HIV patients after they receive antiretroviral (anti-HIV) therapy.
These findings are published in the July 1, 2001, issue of the Journal of Infectious Diseases. The study, which was funded by and conducted at the U.S. Centers for Disease Control and Prevention (CDC), involved 20 HIV infected patients who received antiretroviral therapy over the course of one year.
"We've known for some time that CD4(+) T cells increase after HIV patients receive anti-HIV drug combinations," said Richard Hengel, MD, assistant professor of medicine at Georgetown University Medical Center, Washington, DC, and the lead author of this study. "What this study shows us is that it is a specific type of CD4(+) T-cell that is primarily responsible for this increase: the CD4(+) T cells which traffic through the lymph nodes."
Hengel added that this finding might have important implications for the pathogenesis of HIV and for future HIV vaccine development.
It is in the lymph nodes that immune responses to infection begin, ...
Source: HighBeam Research, Numbers Of CD4(+) T Cells Increase In HIV Patients After...