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Antigen-Pulsed Dendritic Cells Confer Protection In Mice.(Brief Article)
2001 JUL 11 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Bone marrow-derived dendritic cells (bmDC), pulsed with herpes simplex virus 2 (HSV-2) antigens completely protected mice from disease and death after infection with HSV-2, report researchers working in Sweden.
E. Schon and colleagues studied the effect of bmDC pulsed with inactivated HSV-2 or with purified HSV-2 envelope glycoproteins to induce protective immunity in mice. Their results were published in the Journal of Reproductive Immunology.
The vaccine offered complete protection against disease and death but only when delivered intravenously, said Schon and coworkers. Presentation of the antigens by the bmDC was apparently critical, since neither the antigens alone nor the mock-pulsed bmD, prevented disease in these animals.
Schon and team attributed the vaccine's success to HSV-2-specific interferon-gamma and antibody production ("Dendritic cell vaccination protects mice against lethality caused by genital herpes simplex virus type 2 infection," J Reprod Immunol, 2001;50(2):87-104).
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Source: HighBeam Research, Antigen-Pulsed Dendritic Cells Confer Protection In Mice.(Brief...