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Mouse Survival Prolonged With Dendritic Cell Vaccine.(Brief Article)
2001 JUL 4 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Mice immunized with Pseudomonas aeruginosa-pulsed dendritic cells (DC) survive significantly longer after pulmonary infection with P. aeruginosa than unimmunized mice, according to a new study in Infection and Immunity.
"To develop a Pseudomonas aeruginosa vaccine that allows the host immune system to select the antigens, we hypothesized that dendritic cells (DC) pulsed with P. aeruginosa would induce protective immunity against pulmonary infections with P. aeruginosa," said S. Worgall and colleagues at Cornell University's Weill Medical College, New York.
To activate the DC, researchers incubated murine bone marrow-derived DC with P. aeruginosa in vitro. Mice immunized with the resulting P. aeruginosa-pulsed DC showed increasing proliferation of spleen-derived CD4(+) cells, indicative of a specific immune response.
When Worgall and coworkers immunized syngeneic mice with P. aeruginosa-pulsed DC then challenged them with pulmonary P. aeruginosa 13 days later, 45% exhibited prolonged survival (>14 days). In contrast, unimmunized mice or those immunized with naive DC or Escherichia coli- or lipopolysaccharide-stimulated DC and then challenged with P. aeruginosa died within 72 ...
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Source: HighBeam Research, Mouse Survival Prolonged With Dendritic Cell Vaccine.(Brief Article)