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Phase II Findings Of Therapeutic Vaccine Presented.(Brief Article)
2001 JUL 4 - (NewsRx.com & NewsRx.net) --
CancerVax Corporation announced that investigators from the John Wayne Cancer Institute (JWCI) in Santa Monica, California, presented clinical results indicating that its therapeutic cancer vaccine (the CancerVax(TM)) vaccine) confers increased median overall survival and increased five-year overall survival rate in patients with surgically resected Stage IV melanoma.
The Phase II study compared survival of 107 resected patients with Stage IV melanoma to whom the CancerVax vaccine was administered to that of matched control patients who received other therapies. The findings were presented at the 37th Annual Meeting of the American Society of Clinical Oncology (ASCO).
Median survival has been reported to be less than eight months for patients with melanoma that has metastasized to distant sites in the body (Stage IV). However, multiple studies have reported median overall survival of 13 to 18 months for patients undergoing complete surgical resection of the primary tumor as well as clinically detectable metastases.
In this study, a matched-pair analysis based on gender, site of metastasis, and number of tumor-involved organ sites was conducted on 107 matched pairs. Median overall survival and five-year rate of overall survival were 41 months and 42%, respectively, for those patients who received the CancerVax vaccine, compared with 19 months and 19%, respectively, for the non-vaccine group. These differences were statistically significant (p=0.0003 by log rank test). The CancerVax vaccine conferred a survival benefit in patients both with exclusively visceral metastases (N=60) and exclusively non-visceral metastases (N=39).
The significantly higher survival in patients given the ...
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