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DNA Vaccine Protects Mice Against Highly Mutational Influenza.(Brief Article)
2001 JUL 4 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A vaccine that includes plasmid (pME18S-M) containing M1 and M2 genes of influenza A/PR/8/34 offers 70%-80% protection against lethal challenge with influenza A in mice, according to new findings published in Vaccine.
Administration of pME18S-M either intramuscularly or intranasally induced cytotoxic T lymphocyte activity in BALB/c mice, reported K. Okuda and colleagues in Japan. Vaccinated mice also showed influenza A-specific antibody response but not enough to neutralize the virus, they added.
Lethal infection with the A/WSN/33 and A/PR/8/34 strains of influenza A killed all unimmunized mice but conferred 70%-80% protection in pME18S-M-immunized mice, said Okuda and coworkers.
CD8(+) and CD4(+) responses appeared critical to the vaccine's efficacy. When researchers eliminated CD8(+) and CD4(+) cells in mice by injecting anti-CD8(+) and CD4(+) antibodies, the vaccine was significantly less able to protect against infection ("Protective immunity against ...
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Source: HighBeam Research, DNA Vaccine Protects Mice Against Highly Mutational Influenza.(Brief...