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Intra-Spleen DNA Vaccine Stimulates Lymphoid Immune Response.(Brief Article)
2001 JUL 4 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A DNA vaccine administered to the spleen is capable of stimulating immune responses necessary for protective efficacy, according to a new report in DNA Cell Biology.
A. Cano and researchers in Mexico wanted to construct a vaccine that would deliver antigen-presenting cells or antigens into the lymphoid organs, a necessary step to induce protective immune responses in the host.
"We immunized mice by a single intraspleen (i.s.) injection of a DNA construct expressing the immunoglobulin (Ig) heavy-chain variable domain (V(H)) in which the complementarity-determining regions (CDR) had been replaced by a Taenia crassiceps T-cell epitope," reported Cano and coworkers.
They found that the DNA vaccine induced protective cellular immune responses and activated CD8(+) cells, likely due to Ig V(H), which "appeared to be the minimal delivery unit of 'antigenized' Ig capable of inducing T-cell activation in a lymphoid organ," they said ("Intraspleen DNA ...
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