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Proof Of Naturally Acquired Immunity Offers Hope For Vaccine.(Brief Article)
2001 JUL 4 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Infection with the third-largest parasitic killer worldwide, amebiasis, appears to generate natural immunity and thus there is hope for vaccine development, say researchers working in Bangledesh.
Until now, it was unknown whether previous infection generated natural immunity, reported R. Haque and colleagues at the Centre for Health and Population Research in Dhaka. "An investigation was done to determine whether protection from intestinal infection correlated with mucosal or systemic antibody responses to the Entamoeba histolytica GalNAc adherence lectin."
The researchers found that none of the children in their study who had stool immunoglobulin A (IgA) anti-GalNAc lectin antibodies were colonized with E. histolytica, while 13.4% of children without these antibodies had E. histolytica colonization.
Children who had evidence of the antibodies at the beginning of the study had 64% fewer new E. histolytica infections after five months (3/42 IgA(+) vs. 47/227 IgA(-)), said Haque and coworkers.
A stool anti-lectin IgA response was detected near the time of resolution of infection in 67% (12/18) of closely monitored new infections, they added ("Amebiasis and mucosal IgA antibody against the Entamoeba histolytica adherence lectin ...
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