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Stem Cell Tissue Engineering Restores Urethral Sphincter Muscles In Animal Model.(stem cells transplantation to treat stress urinary incontinence)
2001 JUN 14 - (NewsRx Network) -- University of Pittsburgh researchers have successfully used stem cell tissue engineering to restore deficient urethral sphincter muscles in animal models.
They presented their findings on June 5, 2001, at the 96th Annual Meeting of the American Urological Association (AUA), held in Anaheim, California.
Researchers successfully regenerated viable muscle using muscle derived stem cells (MDSC).
"These findings are exciting on many levels. First, this is the first time that stem cell tissue engineering has been used to regenerate and restore function in deficient sphincter muscles. Secondly, it lays the foundation for further investigation into methods of using stem cells to treat stress urinary incontinence," said Michael Chancellor, MD, professor of urology and gynecology at the University of Pittsburgh School of Medicine.
In the study, researchers isolated MDSC from normal rats, transduced them with a reporter gene, and injected the stem cells into allogenic denervated proximal urethral sphincters. After two weeks, they compared urethral muscle strips from normal, denervated and denervated-MDSC injected rats. Fast twitch muscle contractions were recorded after electrical field stimulation.
The amplitude of fast twitch muscle ...
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