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Growth Factor Manipulation Could Blunt Congenital Malformations.(in children of diabetic mothers)
2001 JUN 7 - (NewsRx Network) -- by Sonia Nichols, senior medical writer - Scientists predict therapies that use angiogenic mechanisms could some day prevent congenital malformations in the children of diabetic mothers.
These therapies would override mutations on growth factor genes normally responsible for the development of tissues within the circulatory system during embryonic growth, authors of the new research indicate.
"Major congenital malformations, including those affecting the cardiovascular system, remain the leading cause of mortality and morbidity in infants of diabetic mothers," said Emese Pinter of Yale University School of Medicine, who worked with researchers in Toronto to study the effect of hyperglycemia on growth factor signaling during embryonic development in mice.
In diabetic mothers, glucose accumulation, or hyperglycemia, acts as a toxin, causing abnormal prenatal development. Pinter and associates found that in mice excess glucose disrupted the expression of a growth factor called VEGF (vascular endothelial growth factor), which is responsible for the growth of new blood vessels. This in turn inhibited signals normally sent out by the growth factor's receptor, leading to abnormal vascular development.
These researchers found that the harmful effects of hyperglycemia could be blocked by ...
- Growth Factor Manipulation Could Blunt Congenital Malformations.
- Newspaper article from: Angiogenesis Weekly June 8, 2001 700+ words
...children of diabetic mothers. These therapies...mutations on growth factor genes normally...infants of diabetic mothers," said Emese...hyperglycemia on growth factor signaling during...in mice. In diabetic mothers, glucose accumulation...
- With help, diabetic mothers can breast-feed.(Obstetrics)
- Magazine article from: OB GYN News Boschert, Sherry May 15, 2006 700+ words
...rates of morbidity in infants born to diabetic mothers, a Danish study found. Exclusive...In the current study, 86% of 102 diabetic mothers were breast-feeding 5 days after...months after delivery, 54% of the diabetic mothers were exclusively breast-feeding...
- Cardiac troponin-I found in serum of infants of diabetic mothers.
- Newspaper article from: Diabetes Week September 15, 2003 700+ words
...was found in the serum of infants of diabetic mothers. According to recent research published...previously described in infants of diabetic mothers. When it occurs, it is generally...troponin-I in the serum of infants of diabetic mothers. Cardiol Young, 2003;13(3...
- Iron deficiency alters auditory memory in infants of diabetic mothers.
- Magazine article from: Women's Health Weekly July 29, 2004 700+ words
...memory in newborn infants of diabetic mothers. According to published...United States, "Infants of diabetic mothers (IDMs) are at risk for...memory in newborn infants of diabetic mothers. Pediatr Res, 2004;55...
- Babies of diabetic mothers have fivefold increase in structural heart defects.
- Newspaper article from: Cardiovascular Week October 6, 2003 700+ words
...192,618 babies were born, of whom 609 were born to diabetic mothers. Congenital structural defects of the heart, including...issue of Heart (Cardiovascular malformations in infants of diabetic mothers. Heart, 2003;89:1217-20). The researchers recommend...
- Delivering Gestational Diabetic Mothers.
- Magazine article from: OB GYN News Worcester, Sharon March 15, 2000 700+ words
SARASOTA, FLA. - Shoulder dystocia is a major concern in women with gestational diabetes--even when the baby is estimated to weigh less than 4,000 g, Dr. John F. Huddleston said at a perinatal symposium that was sponsored by Symposia Medicus. "These babies are built like linebackers and they don't
- Similar rates of healthy births found for healthy, in-control diabetic mothers.
- Newspaper article from: Diabetes Week December 23, 2002 700+ words
2002 DEC 23 - (NewsRx.com & NewsRx.net) -- There's good news for expectant mothers who have diabetes, the most common medical complication of pregnancy. Women who are diagnosed with diabetes during pregnancy, who are otherwise healthy and whose glucose is controlled by diet alone deliver
- Growth Factor Supresses Intestinal Lesions.(hepatocyte growth factor suppresses...
- Newspaper article from: Immunotherapy Weekly November 1, 1999 700+ words
...1 - (NewsRx.com) -- Hepatocyte growth factor has been used successfully to suppress...experimental studies of hepatocyte growth factor have suppressed inflammatory bowel...definitive proof of the effect of the growth factor was the more than 50 percent reduction...
