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Major Hurdle In The Development Of An Animal Model Of Hereditary Disease Has Been Overcome.(mouse model of hereditary breast cancer found)
2001 JUN 7 - (NewsRx Network) -- Breast cancer is the most prevalent type of cancer in women, with 192,000 new cases expected this year in the U.S. alone. Despite extensive research efforts, scientists have been unable develop a mouse model of hereditary breast cancer. Until now.
As published in the May 15, 2001, issue of Genes & Development, a collaboration of researchers from Columbia University and the Dana-Farber Cancer Institute have generated a mouse strain with an inherited mutation in Brcal.
The breast and ovarian cancer susceptibility gene, Brcal, is the most commonly detected genetic mutation in familial breast and ovarian cancer. Although structural analysis and in vitro cell culture studies have yielded some clues, the precise function of BRCA1 remains unknown. This work by Efstratiadis and colleagues represents an enormous advance in the determination of BRCA1 function in tumorigenesis.
Several previous attempts have been made to generate ...
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- Magazine article from: Family Practice News JANCIN, BRUCE February 1, 2000 700+ words
...population of women at risk for hereditary breast cancer--and MRI appears to fill...primary screening tool for breast cancer among the general population...surveillance of women at risk of hereditary breast cancer, and he now recommends it...
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- News wire article from: AScribe Medicine News Service November 24, 2003 700+ words
...from the US Department of Defense Breast Cancer Research Program. Satisfaction...evaluation of the effectiveness of the hereditary breast and ovarian cancer helpline for...founded in 1998 by Sue Friedman, a breast cancer survivor and carrier of a BRCA2...
Source: HighBeam Research, Major Hurdle In The Development Of An Animal Model Of Hereditary...