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Comparison Study Suggests Women Taking Lamotrigine Less Likely To Develop PCOS.(polycystic ovary syndrome)
2001 JUN 7 - (NewsRx Network) -- New data from an observational study comparing two commonly used epilepsy treatments, lamotrigine (Lamictal) and valproate (Depakote), suggest that lamotrigine is less likely to be related to disorders associated with polycystic ovary syndrome (PCOS), a condition which causes infertility.
The data were presented in Philadelphia, Pennsylvania, at the 53rd Annual Meeting of the American Academy of Neurology by Dr. Martha Morrell, professor of Neurology at Columbia University College of Physicians & Surgeons and director of the Columbia Comprehensive Epilepsy Center of New York-Presbyterian Hospital.
The international study, which evaluated 222 women aged 18-35, was conducted in response to growing concerns among epilepsy specialists that their female patients may develop hormonal and metabolic disorders related to PCOS when taking anti-epileptic drugs. PCOS is one of the leading causes of infertility in women and is estimated to affect 5%-10% of women of childbearing age. It is characterized by obesity, irregular or absent menses, ovarian cysts, high blood pressure and elevated lipid levels, elevated insulin levels or diabetes, infertility, excessive facial or body hair, and thinning of scalp hair. In particular, several published studies have reported that extended exposure to valproate has been associated with the development of PCOS symptoms.
"Many women with epilepsy receive their treatment from primary care and community physicians who may not be aware of recent information showing that infertility and menstrual disturbances may be associated with some antiepileptic drugs. While this type of study doesn't allow for conclusions about drug-related causation, it certainly adds to the evidence that physicians caring for women with epilepsy should be alert to signs of menstrual irregularity, weight gain and infertility," commented Morrell, who is a recognized expert in the treatment and reproductive health of women with epilepsy.
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