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DNA Immunization Of Mothers May Mean Better Response In Newborns.(Brief Article)
2001 JUN 27 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Immunizing mother mice with naked DNA may ultimately lead to better vaccine efficacy in their offspring, say researchers working in the United States.
D.L. Radu and colleagues proposed that the influence of maternal antibodies could be preventing newborns and infants from receiving full efficacy from influenza vaccines and sought to overcome the problem by immunizing mothers with plasmid DNA.
"We investigated the effect of maternal antibodies on the anti-influenza virus protective response in progeny born to dams immunized with plasmid containing the hemagglutinin [HA] gene or UV-inactivated virus," reported Radu and coworkers.
The researchers immunized BALB/c dams with either virus or plasmid, then studied the effects of immunization on their offspring. They found that the inhibition period of anti-HA antibody response was shorter in mice born to DNA-immunized mice than those born to virus-immunized mice and that the persistent inhibitory effect on B cells continued even after the decline of maternal antibodies in offspring of mice immunized with virus or monoclonal antibodies.
When analyzing specific HA-specific clonotypes, Radu and associates found that "clonotypes producing antibodies specific for the immunizing virus strain were predominant in ...
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Source: HighBeam Research, DNA Immunization Of Mothers May Mean Better Response In...