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IL-12 Suppresses Response To Japanese Encephalitis Plasmid DNA Vaccine.(Brief Article)
2001 JUN 27 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Although interleukin 12 (IL-12) has been shown in previous research to boost immune response when it is used as a vaccine component, researchers in Taiwan warn that it may also have the opposite effect.
Their report in the Journal of Immunology describes IL-12's suppression of immune response when administered prior to or coincident with a Japanese encephalitis plasmid DNA vaccine.
"Co-administration of the IL-12-expressing plasmid (pIL-12) significantly suppressed the protective immunity elicited by a plasmid DNA vaccine (pE) encoding the envelope protein of Japanese encephalitis virus," said H.W. Chen and other researchers at the Institute of Biomedical Sciences in Taipei.
They found that giving pIL-12 with pE in a priming dose prior to booster administration suppressed immune response during subsequent vaccination and that suppression was associated with reduced specific T-cell growth and antibody responses, as well as endogenous production of IFN-gamma ("Suppression of immune response and protective immunity to a Japanese encephalitis virus DNA vaccine by coadministration of an IL-12-expressing plasmid," J Immunol, June 15, 2001;166(12):7419-26).
This suppression was ...
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