AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Vaccine Induces Immunity in Subjects With and Without Infection.(Brief Article)
2001 JUN 27 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A Helicobacter pylori whole-cell (HWC) vaccine can induce immune responses in both H. pylori-infected and -uninfected people.
The HWC vaccine shows the most promise for prevention, rather than treatment, of H. pylori, which is present in half the world's population and causes peptic ulcer, atrophic gastritis, and gastric cancer.
"To explore immunization as a strategy for preventing and treating H. pylori-associated disease, we assessed the safety and immunogenicity in healthy adults of a formalin-inactivated, oral HWC vaccine, administered with or without mutant Escherichia coli heat-labile toxin (LT[R192G]) as a mucosal adjuvant," reported Karen L. Kotloff and colleagues at the University of Maryland.
In separate protocols, 23 subjects with or without H. pylori infection received varying doses of HWC (2.5 x 10(6), 2.5 x 10(8), or 2.5 x 10(10)) plus 25 (micro)g LT[R192G] and 18 subjects infected with H. pylori received one of the following combinations:
* 2.5 x 10(10) HWC plus 25 (micro)g of LT[R192G]
* 2.5 x 10(10) HWC plus placebo-adjuvant
- Research on hepatitis C virus risk factors described by scientists at Medical...
- Newspaper article from: Hepatitis Weekly January 12, 2009 700+ words
...resistance. We studied 40 exposed uninfected subjects testing negative for both HCV antibody...healthy control subjects. All exposed uninfected subjects reported sharing needles or other...found in 23 (58%) of 40 exposed uninfected subjects versus 4 (19%) of 21 control...
- Some Light is Shed on the Transmission of Helicobacter pylori.
- Newspaper article from: Radiology Alert April 1, 2000 700+ words
...from the infected subjects, and uninfected subjects had stool and saliva samples analyzed...cathartic from all infected and uninfected subjects were negative by culture for H...was not obtained from any of the uninfected subjects. The study indicates that H. pylori...
- Vical Reports Third Quarter 2006 Financial Results.
- Press release article from: PR Newswire November 2, 2006 700+ words
...vaccine regimen tested in 40 HIV-uninfected subjects in a National Institutes of Health...combination is being tested in 480 HIV-uninfected subjects through a multinational Phase 2...trial in several thousand HIV-uninfected subjects is expected to begin in early 2007...
- Broad T-Cell Immunity Against HIV Generated in Prime-Boost Vaccine Phase 1...
- Press release article from: PR Newswire August 31, 2006 700+ words
...vaccine regimen tested in 40 HIV-uninfected subjects in a National Institutes of Health...combination is being tested in 480 HIV-uninfected subjects through a multinational Phase 2...trial in several thousand HIV-uninfected subjects is expected to begin in early 2007...
- New findings from University of Pittsburgh in the area of hepatitis C virus...
- Newspaper article from: Heart Disease Weekly August 9, 2009 700+ words
...identified 82,083 HCV-infected and 89,582 HCV-uninfected subjects. HCV-infected subjects were less likely to have hypertension...179 +/- 151 mg/dL) levels, compared with HCV-uninfected subjects (P < .001 for all comparisons). In multivariable...
- Effect of Helicobacter pylori eradication in the glycemia of children with type...
- Magazine article from: Southern Medical Journal Begue, Rodolfo E. Gomez, Ricardo Compton, Terry Vargas, Alfonso August 1, 2002 700+ words
...patients had a UBT. Children with a negative UBT result (implying eradication of H pylon) were then paired with 2 uninfected subjects from the original cohort, matching for potential confounding variables such as age, race, BMI, duration of...
- New research on HIV/AIDS from University of KwaZulu-Natal summarized.
- Newspaper article from: AIDS Weekly June 29, 2009 700+ words
...TRIM5 alpha hu messenger RNA levels were lower in the PBMCs of HIV-1-infected subjects than in those of uninfected subjects (P < .001). Seroconverters had lower preinfection levels of TRIM5 alpha hu than did nonseroconverters...
- OTHER NEWS TO NOTE.
- Magazine article from: BIOWORLD Today March 4, 2002 700+ words
...adenovirus vaccine. Both candidates elicit gag-specific anti-HIV-1 cellular immune responses in HIV-1-uninfected subjects. The HIV-1 gag DNA vaccine candidate used plasmid DNA as a vector. The HIV-1 gag replication-defective...
Source: HighBeam Research, Vaccine Induces Immunity in Subjects With and Without...