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BCG Infections From Vaccine Rare But Possible.(Brief Article)
2001 JUN 20 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Although infection from bacillus Calmette-Guerin vaccine is rare, clinicians should be aware that it does happen, said researchers working in Taiwan.
"We report Mycobacterium bovis BCG infection in two children vaccinated with BCG (Tokyo strain) on the first day of life," said W.J. Su and colleagues.
The infections were diagnosed from biopsies of the children's skin lesions and anterior chest wall abscesses, the researchers said. A negative niacin test, the absence of nitrate reductase, and resistance to pyrazinamide and cycloserine implicated M. bovis BCG as the pathogen, and polymerase chain reaction tests confirmed the diagnoses.
Because the strain was not susceptible to pyrazinamide, the children were treated with rifampicin, isoniazid, and ethambutol. One child was cured but the other, who was immunocompromised, died ("Utility of PCR assays for rapid diagnosis of BCG infection in ...
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Source: HighBeam Research, BCG Infections From Vaccine Rare But Possible.(Brief Article)