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2001 JUN 20 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Contrary to current recommendations, development of a vaccine against typhoid fever should target the youngest children, say researchers working in a highly endemic area of Bangladesh.
S.K. Saha and associates found that infants and young children there were most likely to be affected by typhoid and that bacterial burden was inversely proportional to age.
In their prospective study of patients presenting to a large private diagnostic center in Bangladesh over a 16-month period, they identified 538 bacterial pathogens in 4,650 blood samples, of which 72.7% were Salmonella typhi, for a total incidence of 8.4%.
More than half (54.5%) of the S. typhi isolates were from children younger than five and more than a quarter (27%) were from children two or younger. Saha and team found that the number of bacteria in blood was inversely related to age ("Typhoid fever in Bangladesh: Implications for vaccination policy," Pediatric Infectious Disease Journal May 2001;20(5):521-4).
"Detection of S. typhi bacteremia in young children in Dhaka, ...
Source: HighBeam Research, Youngest Children Have Greatest Disease Burden In Bangladesh.(Brief...