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Vaccines Against Mosquito Midgut Receptors May Limit Transmission.(Brief Article)
2001 JUN 20 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - By preventing development of Plasmodium species in mosquitoes, antibodies targeting the mosquito midgut could eventually halt the global transmission of malaria.
"The mosquito midgut plays a central role in the sporogonic development of malaria parasites," explained A.A. Lal and colleagues at the U.S. Centers for Disease Control and Prevention. "We have found that polyclonal sera, produced against mosquito midguts, blocked the passage of P. falciparum ookinetes across the midgut, leading to a significant reduction of infections in mosquitoes."
Lal and associates developed anti-midgut monoclonal antibodies (mAbs) that not only blocked development of both P. falciparum and P. vivax in five mosquito species but reduced mosquitoes' ability to survive and reproduce.
This activity suggests the potential of a vaccine employing anti-midgut antibodies to hinder the spread of malaria on two levels, said Lal et al.: by preventing infection of mosquitoes and by reducing their numbers ("Anti-mosquito midgut antibodies block development of Plasmodium falciparum and Plasmodium vivax in multiple species of ...
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Source: HighBeam Research, Vaccines Against Mosquito Midgut Receptors May Limit...