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BCG Augments Photodynamic Therapy, Prevents Tumor Recurrence.(Brief Article)
2001 JUN 20 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - The bacillus Calmette-Guerin (BCG) vaccine stimulates an immune response against tumors treated with photodynamic therapy (PDT) in mice and improves the animals' ability to resist tumor recurrence.
M. Korbelik and colleagues in Canada evaluated different regimens for treatment of EMT6 tumors, including BCG, PDT, or various combinations.
They found that a single administration of BCG improved the cure rate of PDT-treated tumors, regardless of the type of photosensitizer used (photofrin, benzoporphyrin derivative, tetra(m-hydroxyphenyl)chlorin (foscan), mono-L-aspartyl-chlorin e6, lutetium texaphyrin or zinc phthalocyanine).
"The interaction does not take place during the early phase of tumor ablation but at later events involved in preventing tumor recurrence," suggested Korbelik and coworkers.
Even when BCG was administered seven days after PDT treatment, tumors were not as likely to reappear, compared with PDT treatment alone ("Interaction between photodynamic therapy and BCG immunotherapy responsible for the reduced recurrence of treated mouse tumors," Photochemistry and Photobiology, 2001;73(4):403-409).
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