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Recombinant PhpA Protein Vaccine Protects Mice From S. pneumoniae.(Brief Article)
2001 JUN 20 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Researchers at Wyeth-Lederle Vaccines may have overcome some of the limitations of the current multivalent pneumococcal conjugate vaccine, according to a report in Infection and Immunity.
Although the current vaccine is effective against systemic Streptococcus pneumoniae and subsequent otitis media, it does not contain all serotypes of the pathogen and thus does not prevent infection with all strains, pointed out Y. Zhang and associates at the company.
"To address these serotypes and the remaining otitis media due to S. pneumoniae, we have been evaluating antigenically conserved proteins from S. pneumoniae as vaccine candidates," they said.
Drawing from previous research that identified a 20-kDa protein with putative C3-proteolytic activity and the publicly released pneumococcal genomic sequences, Zhang and coworkers evaluated a recombinantly expressed 79-kDa fragment (rPhpA-79) that contains a repeated HxxHxH motif for its vaccine potential.
The purified rPhpA-79 protein vaccine elicited antibodies that cross-reacted with multiple strains of S. pneumoniae, the authors reported ("Recombinant PhpA protein, a unique histidine motif-containing protein from Streptococcus pneumoniae, protects mice against intranasal pneumococcal challenge," Infect Immun, June 2001;69(6):3827-36).
Furthermore, mice that were immunized subcutaneously with rPhpA-79 protein plus ...
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Source: HighBeam Research, Recombinant PhpA Protein Vaccine Protects Mice From S....