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Adding GM-CSF To gp100 DNA Vaccine Protects Mice From Tumors.(Brief Article)
2001 JUN 20 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A plasmid cDNA vaccine coding for the melanoma antigen gp100 can protect mice against melanoma tumors, and now researchers have found that adding granulocyte-macrophage colony-stimulating factor (GM-CSF) to the mix makes it even more potent.
A.L. Rakhmilevich and colleagues at the University of Wisconsin found that particle-mediated delivery of gp100 plasmid into the skin of healthy mice protected them from later challenge with melanoma tumor. When gp100 was delivered with GM-CSF, the level of protection increased enough to allow a much lower dose of gp100, they reported.
"Protection from tumor challenge was achieved with as little as 62.5 ng of gp100 DNA per vaccination," noted the Rakhmilevich team, who added that the protection was T-cell mediated since no protective effect was seen in vaccinated mice treated with anti-CD4 and anti-CD8 monoclonal antibodies.
Not only was the combination vaccine effective against subsequent tumor challenge, it also suppressed tumor growth in mice with established seven-day-old melanoma tumors, the authors reported ("Effective particle-mediated vaccination against mouse melanoma by coadministration of plasmid DNA encoding gp100 and granulocyte-macrophage colony-stimulating factor," Clinical Cancer Research, ...
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Source: HighBeam Research, Adding GM-CSF To gp100 DNA Vaccine Protects Mice From Tumors.(Brief...