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Flu Vaccine Stimulates Specific, Not General, Antibody Response In MS Patients.(Brief Article)

Vaccine Weekly

| June 13, 2001 | COPYRIGHT 2001 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2001 JUN 13 - (NewsRx.com & NewsRx.net) --

by N.R. Saltmarsh, staff medical writer - Fears that vaccination against influenza might stimulate central nervous system (CNS) antibodies in multiple sclerosis (MS) patients have been laid to rest, according to a new study in Neurology.

Natural infections can trigger disease activity in MS patients, so researchers wanted to find out whether influenza vaccination stimulated specific or more general immunity in this patient group.

N.F. Moriabadi and colleagues in Germany measured myelin protein-reactive T-cell response to immunization in 12 patients with MS who were not receiving immunosuppressive treatment and in 28 healthy volunteers

Both patient groups had cellular immune responses to influenza A virus at two weeks post-vaccination, reported Moriabadi and coworkers. The MS group showed a higher relative increase in influenza-specific T cells (p=0.008) than controls.

The heightened antibody response did not, however, affect human myelin basic protein (MBP) or recombinant human myelin oligodendrocyte protein (MOG) in MS patients, the researchers found, while incidental febrile infections did stimulate MBP-specific T-cell responses ("Influenza ...

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Source: HighBeam Research, Flu Vaccine Stimulates Specific, Not General, Antibody Response In MS...

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