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Repeated Peptide Vaccination Maintains Tumor Antigen-Specific T Cells.(Brief Article)
2001 JUN 13 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Vaccination with a peptide antigen (Ag) against corresponding Melan-Am/MART-1 Ag can stimulate and maintain high levels of CD8(+) T cells, say researchers working in Switzerland.
M.J. Pittet and associates reported that the frequency of circulating CD8(+) T cells directed against the Melan-Am/MART-1 Ag increased more than 20-fold in an HLA-A2 melanoma patient during repeated immunizations with the corresponding antigenic peptide. Their findings were published in Clinical Cancer Research.
The proportion of these cells that expressed an activated/memory surface phenotype also increased markedly, the researchers said, with a >50-fold increase in cells able to secrete interferon-gamma ("Expansion and functional maturation of human tumor antigen-specific CD8(+) T cells after vaccination with antigenic peptide," Clin Cancer Res, 2001;7(3 Suppl):796S-803S).
Tetramer staining following cell sorting showed that Melan-A-specific cells were weakly cytolytic but became highly active after in vitro restimulation, noted Pittet and team.
"Altogether, these results ...
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Source: HighBeam Research, Repeated Peptide Vaccination Maintains Tumor Antigen-Specific T...