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Nasal Immunization Helps Subdue Corneal Infection By Bacteria.(Brief Article)
2001 JUN 13 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Rats immunized with killed Pseudomonas aeruginosa are better able to resist potentially blinding corneal infection than nonimmunized controls, according to a new report in Infection and Immunity.
Researchers comparing three routes of vaccine delivery found that nasal delivery worked best to protect against P. aeruginosa keratitis, a potentially sight-threatening infection in humans.
A. Thakur and research colleagues sought to define the immune mechanisms involved in P. aeruginosa infections in their study of Sprague-Dawley rats immunized with paraformaldehyde-killed P. aeruginosa (strain 6206) via oral, nasal, and intra-Peyer's patch (IPP) routes.
Following infectious challenge with P. aeruginosa in scratched corneas, immunized rats showed higher infiltration with polymorphonuclear leukocyte (PMN) initially than control rats but then those levels dropped as PMN in controls continued to rise.
Immunized rats, particularly those immunized nasally, cleared bacteria much faster than controls, and nasal and IPP groups showed increased expression of interleukin-2 (IL-2) and IL-5.
All three immunized groups had significantly lower IL-1 beta levels than controls, noted Thakur and colleagues ...
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