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Cerulenin, Leptin Have Similar Metabolic Activity, Different Mechanisms.

Obesity, Fitness & Wellness Week

| May 26, 2001 | Saltmarsh, N.R. | COPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2001 MAY 26 - (NewsRx Network) -- by N.R. Saltmarsh, staff medical writer - Cerulenin mimics the effects of leptin on food intake and metabolic rate in animals but appears to do so using different mechanisms, according to a report in Diabetes.

H. Makimura and colleagues in the United States studied the effects of cerulenin on ob/ob, Ay (agouti), and fed and fasted wild-type mice. They found that cerulenin reduced body weight and food intake and increased metabolic rate in ob/ob mice and wild-type mice, much as leptin did.

But unlike leptin, cerulenin did not prevent the influence of fasting on such neuroendocrine indicators as plasma corticosterone, …

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