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Tat Protein, Component Of HIV Vaccines, Has Been Successfully Produced In Spinach.(Brief Article)
2001 JUN 6 - (NewsRx.com & NewsRx.net) --
The success of combating AIDS in the most affected and least developed parts of the world will ultimately depend upon logistics and economics of vaccine production and delivery in a harsh and very poor environment. Plants represent an inexpensive and safe production and delivery vehicle, especially edible plants like spinach.
The key regulator of the HIV-1 replication, a small protein named tat, has been successfully produced in an edible plant - spinach. This is a first step to the production of a combination vaccine against HIV-1 entirely in plants.
The work was done by Dr. Alexander Karasev and Prof. Hilary Koprowski from the Biotechnology Foundation Laboratories at Thomas Jefferson University in Philadelphia, Pennsylvania, and funded by the Pennsylvania Department of Health. It was reported at the 101st General Meeting of the American Society for Microbiology, held May 20-24, 2001, in Orlando, Florida.
Tat protein has recently been a focus of research as a prospective target for the HIV-1 vaccine development. It is not only a key regulator of virus replication, but also has a broad immunotoxicity, thus promoting AIDS progression in infected individuals. Therefore, tat may be a target not only for vaccine development, but also for a vaccine-based immunotherapy in HIV-1 infected people.
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