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IM Preimmunization With PVRV Confers Best Antibody Protection In Travelers.(Brief Article)
2001 JUN 6 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Rabies vaccination can be given before or after exposure, but even people with adequate immunity to rabies need two follow-up boosters if exposed.
That could be a problem if your doctor is 10,000 miles away.
Rabies deaths have, in fact, been reported in exposed, preimmunized travelers to remote areas who were unable to get booster shots and did not have adequate antibody levels for protection.
To determine the most effective vaccine protocol for rabies prevention, D. Eastman, Brown University, and associates at a Nepal travel clinic, investigated the efficacy of the two pre-exposure vaccines, HDCV and PVRV, in 42 travelers reporting to the CIWEC Travel Clinic in Kathmandu for routine care over a two-month period in 1999-2000.
Study subjects were adults, mean age 35.2 +/-10.9 years, who could provide documentation of rabies preimmunization along with data regarding vaccine type, time since vaccination, administraton route (intradermal or intramuscular), and antimalarial medication type.
Eastman and team submitted frozen serum samples to Kansas State University for measurement of rabies sensitization by Rapid Fluorescence Focus Inhibition Test (RFFIT).
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Source: HighBeam Research, IM Preimmunization With PVRV Confers Best Antibody Protection In...