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Higher Age At Vaccination Confers Better Protection Against Hepatitis B Virus.(Brief Article)
2001 JUN 6 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A follow-up study of Italian children who received the hepatitis B vaccine showed that most still had protective hepatitis B surface antigens (HBs) five years later, but the degree of protection varied.
A. Faustini and colleagues tested 1,192 subjects who were newborns or 11-year-olds in June 1991, when compulsory HBV vaccination was introduced for these two age groups in Italy. Their findings were published in Vaccine.
In 92.9% of the 533 former newborns and 94.1% of the 659 former adolescents, anti-HBs titers were in the protective range of >=10 IU/l. The subjects with protective titers could be categorized as low (10-500 IU/l), medium (501-2000 IU/l), or high (>2000 IU/l) responders ("Persistence of anti-HBs 5 years after the introduction of routine infant and adolescent vaccination in Italy," Vaccine, 2001;19(20-22):2812-2818).
Faustini and associates employed multiple politomic logistic regression analysis to find out which factors were associated with these levels of protection.
Greater age at first dose (11-12 years) was associated with higher titers ...
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Source: HighBeam Research, Higher Age At Vaccination Confers Better Protection Against Hepatitis...