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DNA Vaccine Decreases Ocular Disease Severity And Acute Infection In Trigeminal Nerve.(Brief Article)
2001 JUN 6 - (NewsRx.com & NewsRx.net) --
Researchers have developed a DNA vaccine against herpes simplex virus type 1 (HSV-1) that decreases severity of disease in the eye in mice infected with HSV-1 by the corneal route.
Immunization with the construct also decreases the magnitude of the acute infection of the trigeminal ganglia, the nerve where HSV-1 can establish a latent or non-productive state. Despite the decrease in the acute infection of the trigeminal nerve, latency was still established in immunized mice, reported Tricia Frye and her professors at Wright State University, Dayton, Ohio, and The Immune Response Corp., Carlsbad, California.
HSV-1 is the leading cause of blindness by an infectious agent. Control of the disease within the eye could ameliorate the destruction caused by infection.
Immunized mice were infected with HSV-1 by the corneal route and monitored for 21 days following infection. The mice were scored based on the degree of disease symptoms displayed: weeping eyes, edema, visible lesions. At days 2, 4, 7, 9, and 11 post-infection, the trigeminal ...
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- HSV-1 vaccine prevents clinical changes of HSV-1 encephalitis.
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- HSV vectors with vhs gene deletion offer dendritic cell immunotherapy.
- Newspaper article from: Vaccine Weekly May 7, 2003 700+ words
...replication-incompetent HSV vectors with vhs deleted which...from herpes simplex virus (HSV) relieves the viral block to...activation: Potential of vhs- HSV vectors for dendritic cell...This article was prepared by Vaccine Weekly editors from staff and other...
- Immunization With Mutated HSV-2 May Prevent Transmission.(herpes simplex virus...
- Newspaper article from: Vaccine Weekly March 14, 2001 700+ words
...after genital infection with HSV-2," concluded Morrison and...Herpes simplex virus 2 (HSV-2) is sexually transmitted...Using a replication-defective HSV-2 vaccine, scientists were...This article was prepared by Vaccine Weekly editors from staff and other...
- DNA priming improves HSV-1 amplicon-induced T-cell responses.
- Newspaper article from: Vaccine Weekly July 23, 2003 700+ words
...based on herpes simplex virus (HSV)-1 particles. 2) Priming...elicited by gp120-encoding HSV amplicons. 3) In addition...immunization with gp120-encoding HSV amplicons significantly augmented...This article was prepared by Vaccine Weekly editors from staff and other...