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Fiber-Mutant Adenovirus Vector Yields Efficient Gene Expression In Dendritic Cells.(Brief Article)
2001 JUN 6 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A new fiber-mutant adenovirus vector is better than traditional adenoviruses for genetically modifying dendritic cells (DCs), say researchers working in Japan.
An effective DC vaccine eventually may comprise the fiber-mutant adenovirus (Ad), said N. Okada and associates at Osaka University.
Although DC vaccines have shown promise in recent studies, they have been relatively resistant to gene transfer by Ads, because they lack Coxsackie-adenovirus receptor expression, and because they already express adequate alpha (nu)-integrins, explained Okada et al.
"We investigated whether fiber-mutant Ad containing the Arg-Gly-Asp (RGD) sequence in the fiber knob can efficiently transduce and express high levels of the LacZ gene into DCs," the authors said.
They found that fiber-mutant Ad was more efficient than conventional Ad in gene delivery to both mouse and normal human DCs. In the case of human DCs, the difference in beta-galactosidase activity was 70-fold ("Efficient gene delivery into dendritic cells ...
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Source: HighBeam Research, Fiber-Mutant Adenovirus Vector Yields Efficient Gene Expression In...