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2001 JUN 6 - (NewsRx.com & NewsRx.net) --
Incurring a corneal abrasion, or the use of long-term or extended wear contact lenses, increases the risk of eye infection. The longer lenses are worn without removal, the greater the risk for infection.
Among the microbes that cause such infections, designated as ulcerative keratitis, a gram-negative bacterium, Pseudomonas aeruginosa, is one of the most frequent causes. P. aeruginosa infection can progress rapidly, causing significant damage to the cornea, and if damage cannot be limited, corneal transplants may be the only solution for restoration of vision.
P. aeruginosa infection is also difficult to treat, usually requiring application of topical antibiotics to the corneal surface and injection of antibiotics directly into the eye in the subconjunctival or stromal regions. A therapy that would be efficacious at treating this infection and easier to administer would be highly desirable.
A new type of vaccine to prevent P. aeruginosa infection is under development. This vaccine, which is being developed for delivery in nose drops, is based on a genetically-engineered strain of the microbe that is severely weakened in its ability to grow in human tissue and cause infection.
If infections develop in unvaccinated individuals, however, a different strategy is needed to help treat the infection, according to Dr. Tanweer Zaidi, of Harvard Medical School, who spoke at the 101st General Meeting of the American Society for Microbiology, held May 20-24, 2001, in Orlando, Florida. This strategy, termed passive immunization, relies on delivery to the infected person of antibodies made in other vaccinated individuals. For this strategy to work, the antibodies must be able to help treat an established infection, working in concert with antibiotics and other therapies.
When the weakened P. aeruginosa bacterium is given intranasally to rabbits they have no adverse reactions or consequences and develop ...