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Adding Bile Salts To Oral Vaccines Stimulates Potent Immune Response.(Brief Article)
2001 JUN 6 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Incorporating bile salts into nonionic surfactant vesicles boosts the potency of oral vaccines and may ultimately provide oral alternatives to current parenteral vaccines.
M. Conacher and scientists working in Scotland said that deoxycholate was the most effective bile salt and called the new vesicles bilosomes.
Conacher and team tested the bilosomes with a standard antigen, a synthetic measles peptide, and an influenza subunit vaccine in mice, fine-tuning the protocol until they arrived at the ideal of two doses of vaccine three days apart, repeated two weeks later.
The oral measles vaccine stimulated a specific cell-mediated response, with splenocyte proliferation and interleukin-2 production, while the influenza sub-unit vaccine induced as potent an antibody response as parenterally administered measles vaccine with the same amount of antigen, reported Conacher and coworkers.
Oral bilosome formulations were also comparable to parenteral vaccination in terms of Th1/Th2 balance ("Oral immunisation with peptide and protein antigens by formulation in lipid vesicles incorporating bile salts (Bilosomes)," Vaccine, ...
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Source: HighBeam Research, Adding Bile Salts To Oral Vaccines Stimulates Potent Immune...