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New Vaccine Stimulates Mucosal, Systemic Antibodies in Mice.(Brief Article)
2001 JUN 6 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A vaccine incorporating the recombinant B subunit of the Escherichia coli heat-labile toxin (LTB) completely protects mice from influenza, say researchers working in The Netherlands.
The LTB vaccine stimulated both mucosal and systemic antibodies, a big plus for influenza vaccines, which seem to work best when they can induce local mucosal antibodies as well as systemic responses.
"Local mucosal IgA antibodies play a central role in protection of the respiratory tract against influenza virus infection," L. Dehaan and colleagues at the University of Groningen confirmed.
The researchers had previously demonstrated that LTB is a potent adjuvant for nasally administered influenza subunit antigen and in this study considered whether intranasal (i.n.) or intramuscular (i.m.) delivery is more effective.
Both i.m. and i.n. immunization completely protected mice against the virus, though in different specific ways. Mice immunized i.n. produced antigen-specific serum IgG and mucosal IgA, whereas those immunized i.m. had strong serum and mucosal IgG, but not IgA responses, reported Dehaan and coworkers ...
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Source: HighBeam Research, New Vaccine Stimulates Mucosal, Systemic Antibodies in Mice.(Brief...