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Blood From Multiparous Donors Linked To Lung Injury.
2001 MAY 24 - (NewsRx Network) -- by Michael Greer, senior medical writer - Blood donated by women with multiple children can cause or exacerbate lung injury in intensive care patients, researchers in Sweden warn.
"Transfusion-related acute lung injury (TRALI) and other post-transfusion reactions may be caused by granulocyte and/or HLA antibodies, which are often present in blood from multiparous donors," explained M. Palfi and colleagues at Linkoping University.
Palfi et al. found that blood from women who had given birth three or more times carried a higher risk of negative reactions and provided less benefit to patients.
Plasma from multiparous donors had significantly less oxygen saturation after transfusion than plasma from other donors, study data showed. The researchers also found that blood from women with multiple live births was linked to higher levels of tumor necrosis factor (TNF)-[alpha], a proinflammatoly cytokine.
Palfi and coworkers observed five transfusion-related reactions in the study population of 100 intensive-care patients. Four of these ...
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Source: HighBeam Research, Blood From Multiparous Donors Linked To Lung Injury.