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Common Changes In Body Composition In Premenopausal Patients May Be Preventable With Exercise.
2001 MAY 24 - (NewsRx Network) -- Increasing or maintaining activity levels may help premenopausal patients avoid the weight gain common with chemotherapy for breast cancer, researchers from Duke University Comprehensive Cancer Center and elsewhere reported in the May 2001 issue of the Journal of Clinical Oncology.
The researchers said weight gain is a significant psychological burden for premenopausal breast cancer patients and is also a potential health problem itself. Excess weight is associated with heart disease, diabetes, stroke, and other conditions in the general population. Until now, many oncologists assumed patients were eating too much, but this study, the largest of its kind, says activity is the key.
"Our study does not support over-eating as a cause for weight gain in premenopausal breast cancer patients receiving chemotherapy," said lead author Wendy Demark-Wahnefried, associate research professor in the Department of Surgery. "Chemotherapy patients did not eat more than they did before treatment or when compared to patients not getting chemotherapy. Instead, reduced activity level appears to be responsible."
"Even with concerns about immune system suppression, it's important that patients not cloister themselves throughout their treatment," added co-author Dr. Kelly Marcom, a Duke medical oncologist specializing in breast cancer. 'This research should be a motivator for women getting chemotherapy for breast cancer to stay as active as they can."
The researchers measured and compared diet, activity, resting metabolism, and body composition in premenopausal. early-stage breast cancer patients who received only localized treatment -- surgery with or without radiation treatment -- to those who also received chemotherapy to help minimize the risk of recurrence. The one-year study of 53 patients was funded by the U.S. National Cancer Institute.
"Weight gain is a substantial problem for breast cancer patients getting chemotherapy, particularly for premenopausal women," Marcom said. "Weight loss is generally more associated with other cancers, including lung and pancreatic cancers, but it's not nearly as common with breast cancer."
While most analyses of breast cancer patients have found a significant weight increase for chemotherapy patients compared to those not receiving chemotherapy, in this study the weight gain itself was not as striking as its composition, the researchers said.
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Source: HighBeam Research, Common Changes In Body Composition In Premenopausal Patients May Be...