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Vaginal Infection Treatments Reduce Viral Load.

Women's Health Weekly

| May 10, 2001 | Greer, Michael | COPYRIGHT 2001 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2001 MAY 10 - (NewsRx Network) -- by Michael Greer, staff medical writer - Successful resolution of vaginal infections may significantly reduce the risk of sexual HIV transmission by reducing viral "shedding," according to a University of Washington study.

C.C. Wang and colleagues investigated the benefits of treating a number of different vaginal infections, including Candida vulvovaginitis and Trichomonas vaginitis.

The amount of HIV genetic material in the vaginal area declined sharply after successful treatment of these conditions, which should translate into a reduced transmission risk, Wang et al. said.

Average vaginal levels of HIV-1 RNA dropped by almost half a log step after resolution of C. vulvovaginitis, from 3.36 log copies per swab to 2.86, Wang et al. said. In addition, the prevalence of HIV DNA fell from 36% to 17% after successful treatment.

The researchers found similar results after treating women infected with T. vaginitis in addition to HIV. In these women, successful therapy reduced the vaginal viral load to 3.05 log from a high of 3.67 log copies per swab. HIV DNA prevalence remained the same even ...

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