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DNA Vaccine Offers Post-Exposure Protection In Mice.(Brief Article)
2001 MAY 23 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Researchers with the U.S. National Institute of Allergy and Infectious Diseases have developed a DNA vaccine against rabies that offers post-exposure protection comparable to currently used cell-culture vaccines.
Though DNA vaccines have shown pre-exposure protection in animals, they have not been protective after exposure, probably due to lagging antibody production, said D.L. Lodmell and colleagues.
They manipulated variables such as booster frequency and route of administration to achieve a DNA vaccine that stimulated anti-rabies antibodies five days after the first immunization.
Eighty-seven percent of mice that received the DNA vaccine six hours after rabies infection were protected, compared with 75% that received the cell culture-derived human diploid cell vaccine (HDCV) and none that received anti-rabies immune serum ("Post-exposure DNA vaccination protects mice against rabies virus," Vaccine, 2001;19(17-19 Sp.):2468-2473).
"Post-exposure therapy, ...
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