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Peptide Vaccine Induces Immune Response In 80% Of Trial Patients.(Brief Article)
2001 MAY 23 - (NewsRx.com & NewsRx.net) --
The Immune Response Corp. (IMNR) has published data on its investigational T-Cell Receptor (TCR) peptide vaccine for multiple sclerosis (MS) showing that it induced a specific response (stimulation index >5) in 80% of the patients treated.
The objective of the company's TCR vaccine program is to induce an immune response that inactivates the T cells thought to be pathogenic in MS. The article appears in the May 2001 issue of the Journal of Neuroscience Research.
Eight of 10 patients given five 300-(micro)gram injections of the TCR peptides emulsified in Incomplete Freund's Adjuvant (IFA) during the 48-week, open-label trial developed specific cell mediated responses as measured by both delayed-type hypersensitive (DTH) skin tests and lymphocyte proliferation assays (LPA). No responses against an irrelevant peptide were observed, and neurologic assessments, on average, remained stable during the trial.
"These data, from our ...
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...restricted melanoma peptide, resected nonmetastatic melanoma patients can mount a significant antigen-specific CD8+ T-cell immune response with a functionally intact memory component. The data further support the combined use of tetramer binding and functional...
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...patients with vaccine immune response was significantly longer...of patients with no immune response (21.3 versus 13...Pittsburgh (see also Peptide Vaccine). The researchers concluded: "Immune response to vaccination correlates...
- Peptide vaccine shows promise against schistosomiasis and fascioliasis.
- Newspaper article from: Health & Medicine Week April 19, 2004 700+ words
...An experimental bivalent peptide vaccine shows promise against schistosomiasis...capable of inducing a protective immune response against Schistosoma mansoni...An experimental bivalent peptide vaccine against schistosomiasis and...
- NEW JAPAN PEPTIDE VACCINE HOLDS PROMISE AGAINST VIRUSES, CANCER.
- News wire article from: AsiaPulse News February 9, 2007 700+ words
...promising new kind of peptide vaccine technology to fight...body generate an immune response. The thinking is...the body, existing peptide vaccine strategies require...the body once the immune response has been activated...
- CEL-SCI receives United States patent for use of peptide vaccine technology for...
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- Synthetic peptide vaccine that targets sperm developed for contraception.
- Newspaper article from: Health & Medicine Week April 26, 2004 700+ words
...developed a human synthetic peptide vaccine that targets sperm for contraception...raising a sperm-specific immune response," stated Naz. "The contraceptive...Andrology (Human synthetic peptide vaccine for contraception targeting...
- CTL precursor-oriented peptide vaccine promising for colorectal cancer.
- Newspaper article from: Cancer Weekly July 6, 2004 700+ words
...precursors in the circulation (CTL precursor-oriented peptide vaccine)." "No severe adverse effect was observed, although...five patients demonstrated an increased peptide-specific immune response to the peptides. Increased CTL response to cancer cells...
- The Immune Response Corporation Granted U.S. Patent for the Use of Antibodies...
- Press release article from: PR Newswire April 26, 2001 700+ words
...Research Operations for The Immune Response Corporation. "This...Vbeta TCR peptides. The Immune Response Corporation's Vbeta TCR peptide vaccine, RAVAX(TM), has...sclerosis and psoriasis. The Immune Response Corporation is a biopharmaceutical...
- Peptide vaccine can produce complete remission in myeloid leukemia patients.
- Newspaper article from: Cancer Weekly December 28, 2004 700+ words
...The experimental vaccine produced an immune response in 60% of patients tested - or 20...Of those 20 patients who mounted an immune response against their cancer, 14 had an overall...that some of these patients had an immune response, but they also went into remission...
Source: HighBeam Research, Peptide Vaccine Induces Immune Response In 80% Of Trial...