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DCs Loaded With Apoptotic Leukemia Cells Successfully Immunize Mice.(Brief Article)
2001 MAY 23 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Dendritic cells (DCs) stimulated in vitro with bone-marrow-derived leukemia cells can protect mice from leukemia, according to a report in Cancer Research.
This study offered the first evidence that DCs loaded with apoptotic leukemia cells could protect against the disease, said S. Paczesny and associates in France.
"DCs are professional antigen-presenting cells (APCs) that need to be activated before they can function to initiate primary and secondary immune responses in vivo," explained Paczesny and coworkers.
These researchers extracted DCs from mouse bone marrow and activated them in vitro by exogenous signals from apoptotic leukemia cells that expressed a model tumor-associated antigen.
They then injected mice with these activated DCs, which stimulated antigen-specific immune responses that protected them from leukemia ("Protection of mice against leukemia after vaccination ...
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Source: HighBeam Research, DCs Loaded With Apoptotic Leukemia Cells Successfully Immunize...