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Adding KLH to Dendritic Cell Vaccines Boosts Anti-Tumor Activity.(Brief Article)
2001 MAY 23 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Adding keyhole limpet hemocyanin (KLH) to dendritic cell vaccines can make them work harder. That translates to potent immune effects and rejection of established tumors in vivo, according to a new study published in Cancer Research.
K. Shimizu and colleagues in the United States evaluated the effect of KLH, a foreign helper protein, on tumor lysate-pulsed dendritic cells and peptide-pulsed DC immunizations in vivo.
"Besides being used as a 'surrogate antigen' in approaches to measure immunological response in cancer patients, KLH is also an immunogenic carrier protein to elicit T-cell help," explained Shimizu and associates.
They found that DCs pulsed with both KLH and tumor lysate enhanced immunity and rejection of established melanoma metastases in vivo. Cure rates and overall survival indicated that interleukin 2 further augmented this effect.
Adding KLH to DC immunizations enhanced tumor-specific T-cell production of interferon-gamma (IFN-gamma), reported Shimizu and team.
DCs pulsed with KLH and mouse tyrosinase-related protein-2 peptide showed enhanced reduction of B16 melanoma metastases while tyrosinase-related protein-2 ...
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...Holtl and coauthors published their study in Clinical Cancer Research (Immunotherapy of metastatic renal cell carcinoma with tumor lysate-pulsed autologous dendritic cells. Clin Cancer Res, 2002;8(11):3369-3376). For additional information, contact...
Source: HighBeam Research, Adding KLH to Dendritic Cell Vaccines Boosts Anti-Tumor...