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HIV Epitopes Found In Persistently Seronegative Sex Workers Could Aid Vaccine Development.(Brief Article)
2001 MAY 23 - (NewsRx.com & NewsRx.net) --
An ideal AIDS vaccine might be one that stimulates the cellular immune system so efficiently that, despite repeated exposure to HIV, an individual never shows signs of viremia or even seroconverts against HIV epitopes.
It is still far from clear how to provide anyone this level of protection, but accumulating data from a cohort of at-risk women - sex workers in the AIDS-ravaged community of Nairobi - hint at some of the properties of an immune system that can apparently repel the virus despite ongoing exposure.
Rupert Kaul at the University of Nairobi and the Weatherall Institute of Molecular Medicine at John Radcliffe Hospital, Oxford, U.K., along with colleagues at those institutions and in Canada, have followed this group for some years, and they have found that persistently seronegative women seem to be protected by a vigorous T-cell-mediated response to infected cells, while those who have seroconverted eventually succumb to the disease.
These ...
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Source: HighBeam Research, HIV Epitopes Found In Persistently Seronegative Sex Workers Could Aid...