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Yeast Stimulates Potent Dendritic Cell Response.(Brief Article)
2001 MAY 23 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Recombinant yeast are able to stimulate cell-mediated immunity via dendritic cells and thus may prove to be useful vaccine adjuvants.
"There is currently a need for vaccines that stimulate cell-mediated immunity - particularly that mediated by CD8(+) cytotoxic T lymphocytes (CTLs) - against viral and tumor antigens," explained A.C. Stubbs and team in the United States.
The unique ability of dendritic cells (DCs) to process exogenous antigens and to activate naive, antigen-specific CD8(+) and CD4(+) T cells, makes them ideal for stimulating cell-mediated immunity, wrote Stubbs and associates in Nature Medicine.
They investigated the ability of whole recombinant Saccharomyces cerevisiae yeast expressing tumor or HIV-1 antigens to interact with DCs and induce immune responses in animals.
Interactions between S. cerevisiae and DCs led to DC maturation, interleukin-12 production and potent antigen-specific T-cell responses, including those affording tumor protection, reported Stubbs and colleagues.
"The yeast exerted a strong adjuvant effect, augmenting DC presentation of exogenous whole-protein ...
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Source: HighBeam Research, Yeast Stimulates Potent Dendritic Cell Response.(Brief Article)