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Pneumococcal Polysaccharide Antigens Upregulate Immune Response In Children.(Brief Article)
2001 MAY 16 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Pneumococcal polysaccharide antigens increase CD40 ligand (CD40L) and T helper 2 (Th2) expression both in vitro and in children receiving the pneumococcal vaccine, study results show.
"We wished to determine whether pneumococcal polysaccharide antigens induce mRNA expression of CD40L and Th1 or Th2 cytokines in unimmunized individuals in vitro and whether immunization with the 23-valent pneumococcal polysaccharide vaccine induces changes in CD40L and cytokine mRNA expression," said L.E. Leiva and colleagues at Louisiana State University.
They measured serum and in vitro immune responses for children with recurrent respiratory infections before and four-to-six weeks after pneumococcal vaccination. Unimmunized healthy adults were included as controls.
Reverse transcription polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) PCR revealed a significant increase in the expression of mRNA for CD40L and interleukin (IL) 4, but not IL-12p40 or interferon (IFN) gamma, in stimulated cultures from unimmunized individuals.
ELISA measurements showed CD40L and IL-4 mRNA expression was significantly higher in post-immunization than in pre-immunization samples stimulated with the individual pneumococcal serotypes ("Up-regulation of CD40 ligand and induction of a ...
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Source: HighBeam Research, Pneumococcal Polysaccharide Antigens Upregulate Immune Response In...