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Intranasal Vaccine Delivery Stimulates Potent Immune Response.(Brief Article)
2001 MAY 16 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A new intranasal influenza vaccine performs better than several other delivery systems and stimulates strong immune responses in pigs, report Chiron Corporation researchers.
"A commercially available influenza vaccine, containing hemagglutinin (HA) from influenza/A Johannesberg H1N1 1996, and LTK63 or LTR72 adjuvants, which are generically detoxified derivatives of heat-labile enterotoxin from Escherichia coli, were administered in a bioadhesive delivery system, which comprised esterified hyaluronic acid microspheres, to mice, rabbits and micro-pigs at days 0 and 28," said M. Singh and colleagues.
They compared the bioadhesive delivery system to intranasal administration of HA vaccine alone or with soluble HA + LTK63, or intramuscular (IM) vaccination with HA.
All three groups of animals receiving the bioadhesive vaccine with the mucosal adjuvants had significantly enhanced serum immunoglobulin G (IgG) responses, higher HA inhibition, and significantly enhanced nasal wash IgA responses than the animals receiving other formulations or IM injection.
In pigs, the bioadhesive delivery system ...
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Source: HighBeam Research, Intranasal Vaccine Delivery Stimulates Potent Immune Response.(Brief...