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CDR2 BV6S2/6S5 Peptide Vaccine Safe And Immunogenic.(Brief Article)
2001 MAY 16 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Eight of 10 patients with multiple sclerosis (MS) developed peptide-specific immune responses after being immunized with a T-cell receptor (TCR) V(beta) vaccine, reported researchers with Immune Response Corporation.
E.E. Morgan and colleagues described earlier studies showing that MS patients overexpressed activated T cells from specific TCR V(beta) families, including BV6S2/S5, and that peptide vaccines to the overexpressed V(beta) 8.2 TCR can prevent myelin basic protein (MBP)-induced disease in rats.
In this study, the researchers immunized 10 MS patients with 300 (micro)g of BV6S2/6S5 peptide emulsified in incomplete Freund's adjuvant. Their results were published in the May 2001 issue of the Journal of Neuroscience Research.
No serious adverse effects were reported during the 48-week trial, and eight of the 10 subjects showed cell-mediated immunity to the immunizing peptide ("Vaccination with a CDR2 BV6S2/6S5 peptide in adjuvant induces peptide-specific T-cell responses in patients with multiple sclerosis," J Neurosci Res May 1, 2001;64(3):298-301).
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Source: HighBeam Research, CDR2 BV6S2/6S5 Peptide Vaccine Safe And Immunogenic.(Brief Article)