AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Vaccine Effective Against Virulent Bacterial Strains In Rabbits, Macaques.(Brief Article)
2001 MAY 16 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A licensed human anthrax vaccine (Anthrax Vaccine Adsorbed [AVA]) protects 80%-100% of rabbits and rhesus macaques from challenge with Bacillus anthracis, say researchers at the U.S. Army Medical Research Institute of Infectious Diseases.
AVA's efficacy is not as reliable in guinea pigs, however, reported P.F. Fellows and associates.
They investigated AVA against spore challenge by B. anthracis isolates of diverse geographical origin, starting with 33 isolates given intramuscularly to guinea pigs. The guinea pigs had been vaccinated at 0 and 4 weeks and challenged with B. anthracis at 10 weeks. Survival among the various groups ranged from 6% to 100%.
The researchers then infected AVA-vaccinated rabbits by aerosol challenge with six of the strains that had proved most virulent in guinea pigs. This time, the protection rate was more impressive: 100% protection in four groups and 90% protection in the remaining two.
Finally, Fellows and coworkers challenged rhesus macaques with the two strains that were most virulent in rabbits, also by the aerosol route.
Protection from these two isolates was 80% and 100% ("Efficacy of a human anthrax vaccine in guinea pigs, rabbits, and rhesus macaques against challenge by Bacillus anthracis ...
- Doctors: Anthrax Vaccine Decision Right for Military; Now Apply to Children.
- News wire article from: The America's Intelligence Wire December 23, 2003 700+ words
...administering the anthrax vaccine to military service...adverse reactions to the anthrax vaccine are high -- one...vaccination mandate. "The anthrax vaccine is not the only vaccine...that they serve as guinea pigs for experimental drugs...
- India to offer anthrax vaccine soon.
- Newspaper article from: Statesman (India) November 5, 2001 700+ words
...have developed an anthrax vaccine which will be free...and 100 per cent on guinea pigs. It will be more...It (size of the anthrax vaccine market) could be...trials. Recombinant anthrax vaccine will be the first...
- Most postal workers refuse anthrax vaccine.
- News wire article from: UPI NewsTrack January 26, 2009 700+ words
...shaped partially by fears of being "guinea pigs," disagreements among public health...days with or without a supplemental anthrax vaccine. The study found 11.5 percent of...dose of antibiotics agreed to take the anthrax vaccine as a precautionary measure. The findings...
- Judge Sees Little Evidence To Support Anthrax Vaccine.
- News wire article from: Asia Africa Intelligence Wire May 26, 2004 700+ words
...scientific evidence to show that the anthrax vaccine required for military personnel is...U.S. troops have been given the anthrax vaccine since the program became mandatory...could not require troops to "serve as guinea pigs for experimental drugs" pending a...
- VaxGen Awarded $80.3 Million NIAID Contract for Advanced Development of Anthrax...
- Press release article from: PR Newswire October 1, 2003 700+ words
...for the advanced development of its anthrax vaccine candidate, rPA102. The 3-year...contract for a national stockpile of anthrax vaccine. (Logo: http://www.newscom...recombinant Protective Antigen (rPA) anthrax vaccine, pending legislation known as Project...
- VaxGen Completes Development Activity in Support of Anthrax Vaccine Partnering...
- Press release article from: PR Newswire May 24, 2007 700+ words
...further development of its recombinant anthrax vaccine and is laying off 20 employees, or...support ongoing efforts to partner its anthrax vaccine program and was based on the Department...procurement of a next-generation anthrax vaccine. (Logo: NewsCom: http://www...
- Citizen Petition Filed Yesterday at the FDA: Anthrax Vaccine Network Supports...
- Press release article from: PR Newswire October 16, 2001 700+ words
...Michigan firm which manufactures the anthrax vaccine. The petition calls for the FDA to...on the drug category placement of anthrax vaccine as Category II (unsafe, ineffective...declare as adulterated all stockpiles of anthrax vaccine adsorbed in the possession of BioPort...
- VaxGen Responds to Media Report Regarding Proposed Congressional Investigation...
- Press release article from: PR Newswire April 6, 2006 700+ words
...investigation into the company's anthrax vaccine contract by Congressman Mike Rogers...investigation of our Project BioShield anthrax vaccine contract, because: -- The Department...contract for 75 million doses of a modern anthrax vaccine to VaxGen was the result of an open...
- Anthrax Vaccine Award Rescheduled to Nov. 5; VaxGen Believes It Is the Only...
- Press release article from: PR Newswire October 15, 2004 700+ words
...million doses of a recombinant anthrax vaccine to the U.S. government...VaxGen has been developing its anthrax vaccine candidate, rPA102, to address...for a modern recombinant anthrax vaccine, based on a single defined...
- Dynavax Anthrax Vaccine Induces High Antibody Responses and Shows Protection in...
- Press release article from: PR Newswire March 21, 2005 700+ words
...immunostimulatory sequence (ISS) based anthrax vaccine has the potential to confer...to the currently available anthrax vaccine and a prototype second-generation...Our novel, proprietary anthrax vaccine formulation has potential...
Source: HighBeam Research, Vaccine Effective Against Virulent Bacterial Strains In Rabbits,...