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New Antigen May Figure Into Vaccine Development.(Brief Article)
2001 MAY 16 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A Helicobacter pylori adhesin combined with cholera toxin conferred protection to more than 60% of mice infected with H. pylori and could be a component of future vaccines.
"To evaluate the efficacy of a possible vaccine antigen against H. pylori infection, the chimeric construct adhesin CTXA2B, derived from H. pylori adhesin genetically coupled to cholera toxin (CTX) subunits A2 and B (CTXA2B), was expressed in Escherichia coli as an insoluble recombinant chimeric protein," reported B.O. Kim and colleagues at Sung Kyun Kwan University, South Korea.
They administered oral adhesin-CTXA2B combination or either agent individually to mice. Mice that received both agents produced higher levels of mucosal immunoglobulin A and serum immunoglobulin G antibodies to H. pylori adhesin and to CTXB than mice that received one or the other.
The adhesin-CTXA2B vaccine also protected 62.5% of mice from infection with the SSI strain of H. pylori while either agent alone offered no protection ("Peroral immunization with Helicobacter pylori adhesin protein genetically linked to cholera toxin A2B subunits," Clin Sci, 2001;100(3):291-298).
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