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Electropermeabilization Enhances Response To Nucleic Acid Vaccination.(Brief Article)
2001 MAY 9 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - When electropermeabilization (EP) is used with naked DNA vaccination in animals, transgene expression increases up to 83-fold compared to naked DNA injection alone, researchers report.
"Skin is an ideal target for nucleic acid vaccine (NAV) due to ease of administration and the accessibility of large numbers of antigen-presenting cells within the tissue," noted J.J Drabick and colleagues at the MIST Institute in Rockville, Maryland.
Their work with pigs indicated that transfected cells were mainly located in the dermis and in lymph nodes draining electropermeabilized sites, following DNA injection of 50 (micro)g.
In mice vaccinated with hepatitis B virus small antigen (HBV sAg) protein, EP strongly enhanced immune response, with a Th1-dominant mixed-response pattern, while mice vaccinated with HBV sAg protein alone showed an exclusively Th2 pattern ("Cutaneous transfection and immune responses to intradermal nucleic acid vaccination are significantly enhanced by in vivo electropermeabilization," Molecular Therapy, ...
- Electropermeabilization Enhances Response To Nucleic Acid Vaccination.
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