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DNA Vaccine Protects Mice From Lung Infection.(Brief Article)
2001 MAY 9 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A vaccine based on the Pseudomonas aeruginosa outer membrane porin protein OprF produced OprF-specific antibodies in mice and protected them from P. aeruginosa lung infection in a recent study.
B.M. Price and colleagues at Ohio State University cloned OprF to plasmid vector pVR1020 and delivered the vaccine to mice via gene gun intradermal inoculation. Enzyme-linked immunosorbent assay (ELISA) followed by immunoblotting showed the elicited antibodies were specifically reactive to OprF, they reported.
Compared to control mice, sera from immunized mice had significantly greater opsonic activity, noted Price et al. Initial immunization followed by two boosts two weeks apart also conferred protection against challenge with chronic pulmonary P. aeruginosa infection, they added.
Eight days post-challenge, mouse lungs showed a reduction in severe macroscopic lesions and in bacterial load ("Protection against Pseudomonas aeruginosa chronic lung infection in mice by genetic immunization against outer membrane protein F (OprF) of P. ...
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Source: HighBeam Research, DNA Vaccine Protects Mice From Lung Infection.(Brief Article)