AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Interferon Therapy Does Not Inhibit GMK Vaccine Effectiveness.(Brief Article)
2001 MAY 9 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Giving high-dose interferon therapy with the GM2-KLH/QS-21 (GMK) vaccine does not inhibit immune response and appears to prolong relapse-free survival in high-risk melanoma patients.
High-dose interferon alfa 2b (IFN alpha 2b) is the only established adjuvant therapy of resectable high-risk melanoma, while GMK is one of the best vaccine candidates for the disease.
J.M. Kirkwood and colleagues at the University of Pittsburgh Medical Center, Pennsylvania, proposed that both given together might be more effective than either alone.
Their Phase II study evaluated the combination of GMK and IFN alpha 2b in resectable high-risk American Joint Committee on Cancer (AJCC) stage IIB or III melanoma in 107 patients.
The researchers found that IFN alpha 2b does not significantly inhibit immune response to the vaccine and that the combination is well-tolerated. Furthermore, the dual therapy appears to prolong relapse-free survival in this patient group ("High-dose interferon alfa-2b does not diminish antibody response to GM2 vaccination in patients with resected melanoma: Results of the multi-center Eastern Cooperative Oncology Group Phase II trial E2696," Journal of Clinical Oncology, 2001;19(5):1430-1436).
"Cox ...
- Flamel Technologies Announces Positive Preliminary Results of a Phase I/II...
- Press release article from: Business Wire September 23, 2005 700+ words
...tolerability, and long-acting activity of IFN-alpha-XL in patients with chronic hepatitis...HCV) infection. Data also show that IFN-alpha-XL had positive effects on viral load and interferon activity biomarkers. IFN-alpha-XL utilizes Flamel's proprietary...
- Nautilus Biotech Announces Progress on Belerofon(TM), an Improved IFN Alpha...
- Press release article from: PR Newswire March 23, 2004 700+ words
...successful completion of comparative monkey studies between Nautilus proprietary IFN alpha (Belerofon(TM)) and two leading commercial IFN alpha drugs: native IFN alpha and pegylated IFN alpha. Belerofon(TM) is a single amino acid variant of...
- Flamel Technologies Announces Positive Top Line Results of a Clinical Trial of...
- Press release article from: Business Wire October 25, 2007 700+ words
...tolerability, and long-acting activity of IFN-alpha-XL versus ViraferonPeg[TM], marketed...reduction in side effects for patients given IFN-alpha-XL compared with those who received...ribavirin treatment) who received 27 MIU of IFN-alpha-XL compared with similar patients who...
- Endogenous IFN-alpha/beta may play multiple regulatory roles.(interferon)
- Newspaper article from: Cancer Weekly January 14, 2003 700+ words
...to respond to endogenous interferon (IFN)-alpha/beta (through a mutation in the IFN-alpha/beta receptor) leads to increased susceptibility...antiangiogenic molecules. Interferon (IFN)-alpha and -beta inhibit angiogenesis through...
- Endogenous IFN-alpha/beta may play multiple regulatory roles.
- Newspaper article from: Angiogenesis Weekly January 17, 2003 700+ words
...to respond to endogenous interferon (IFN)-alpha/beta (through a mutation in the IFN-alpha/beta receptor) leads to increased susceptibility...antiangiogenic molecules. Interferon (IFN)-alpha and -beta inhibit angiogenesis through...
- Verotoxin and IFN-alpha have synergistic effect on erythropoiesis.
- Newspaper article from: TB & Outbreaks Week March 30, 2004 700+ words
...NewsRx.net) -- Bacterial verotoxin and IFN-alpha have a synergistic effect on erythropoiesis...ceramide is involved in interferon-alpha (IFN-alpha) signalmg pathways." In their study...verotoxin used in combination with IFN-alpha had a direct cytotoxic effect on erythrocyte...
- IFNAR1-mRNA expression in PBMC associated with IFN-alpha response to hepatitis...
- Newspaper article from: Medical Devices & Surgical Technology Week August 1, 2004 700+ words
...expression in PBMCs is associated with IFN-alpha response to hepatitis C. According to...Biological Research, "Interferon (IFN)-alpha receptor mRNA expression in liver of...C has been shown to be a response to IFN-alpha therapy. "The objective of the present...
- IFN-alpha priming results in a gain of proinflammatory function by IL-10.
- Newspaper article from: Immunotherapy Weekly July 21, 2004 700+ words
...NewsRx.com & NewsRx.net) -- IFN-alpha priming results in a gain of proinflammatory...macrophages with low concentrations of IFN-alpha diminished the ability of IL-10 to suppress TNF-alpha production. IFN-alpha conferred a proinflammatory gain of function...
