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Phase I Clinical Trial Of Plasmid DNA-Based Vaccine Is Enrolling Patients.(Brief Article)
2001 MAY 9 - (NewsRx.com & NewsRx.net) --
A Phase I, placebo-controlled study to examine the safety, tolerability, and immunogenicity of an experimental HIV vaccine consisting of plasmid DNA.
The manufacturer of the experimental vaccine is Merck & Co., Inc.
Vaccination will take place at Day 0 and at Weeks 4, 8, and 26. Patients will be followed for 104 weeks.
Initially, 16 volunteers will be randomized to receive either the HIV-1 gag DNA vaccine at a 1-mg dose or placebo. These volunteers will be observed for adverse events for two weeks after the Week 4 vaccination. If there are no significant adverse effects, Stage 2 will begin.
In Stage 2, 16 patients will receive vaccine at a 5-mg dose or placebo. These 16 patients will be observed for two weeks after the Week 4 injection. If it is determined that the ...
<400, CD4>- Co-Encapsulation of Antigen and Plasmid DNA Improves Response.(Brief Article)
- Newspaper article from: Vaccine Weekly March 29, 2000 700+ words
...protein antigen with plasmid DNA antigen improves the...of both antigen and plasmid DNA encoding antigen can...protein antigen with plasmid DNA improves immune response...article was prepared by Vaccine Weekly editors from staff and...
- Inoculation of plasmid DNA induced expression of LacZ gene.
- Newspaper article from: Vaccine Weekly June 23, 2004 700+ words
...of beta-gal by the plasmid DNA is limited in the muscle...gene inserted in the plasmid DNA for immunotherapy...intramuscular inoculation of a plasmid DNA. J Vet Med Sci, 2004...article was prepared by Vaccine Weekly editors from staff and...
- Plasmid DNA Vaccine Safe And Well-Tolerated In Animal Models.(Brief Article)
- Newspaper article from: Vaccine Weekly August 8, 2001 700+ words
...GM-CSF adjuvant-plasmid DNA malaria vaccine, Gene...malaria comprises five plasmid DNA encoding five proteins...falciparum and one plasmid DNA encoding human GM...article was prepared by Vaccine Weekly editors from staff and...
- Plasmid DNA on nanoparticles offers effective delivery of antigen.(Brief...
- Newspaper article from: Vaccine Weekly October 2, 2002 700+ words
...were successfully coated with plasmid DNA (pDNA) * Plasmid DNA coated on cationic nanoparticles...than did "naked" pDNA * Plasmid DNA coated on cationic nanoparticles...This article was prepared by Vaccine Weekly editors from staff and other...
- Polycation-mediated precipitation captures plasmid DNA from alkaline lysate.
- Newspaper article from: Vaccine Weekly November 3, 2004 700+ words
...precipitation captures plasmid DNA from alkaline lysate...the polycation and the plasmid DNA resulted in the formation...step in purification of plasmid DNA from a clarified lysate...article was prepared by Vaccine Weekly editors from staff and...
- Microparticle adjuvant formulation for plasmid DNA vaccines characterized.
- Newspaper article from: Vaccine Weekly September 1, 2004 700+ words
...adjuvant formulation for plasmid DNA vaccines. "We describe...immunological evaluation of plasmid DNA vaccine formulations containing...adjuvant formulation for plasmid DNA vaccines. J Pharm Sci...This article was prepared by Vaccine Weekly editors from staff and ...
- Plasmid DNA activates dendritic cells via toll-like receptor 9.
- Newspaper article from: Vaccine Weekly January 21, 2004 700+ words
...Vaccination with plasmid DNA activates dendritic...repeated vaccination with plasmid DNA, priming of OVA-specific...Immunology (Vaccination with plasmid DNA activates dendritic...article was prepared by Vaccine Weekly editors from staff and...
- Microparticles act as carriers to deliver plasmid DNA in vaccines.
- Newspaper article from: Vaccine Weekly August 4, 2004 700+ words
...for the delivery of plasmid DNA for vaccine development...Berkeley. "Encapsulated plasmid DNA demonstrated immunostimulatory...for the delivery of plasmid DNA for vaccine development...article was prepared by Vaccine Weekly editors from staff and...